PARADIGHM
(Physicians Advancing Disease Knowledge in Hypoparathyroidism)
PARADIGHM
(Physicians Advancing Disease Knowledge in Hypoparathyroidism)
A Natural History Registry for Patients With Chronic Hypoparathyroidism
This is a prospective, observational, natural history registry, designed to collect data on patients with chronic hypoparathyroidism. No study-defined procedures will be required, and if available, a select set of data will be collected at baseline and at least annually.
Inclusion Criteria:
A patient must meet all of the following criteria to be eligible for participation in the study:
Patients of any age or gender, with a diagnosis of chronic hypoparathyroidism before enrollment. Chronic hypoparathyroidism, is defined as one of the following:
1. PTH value unequivocally low in the presence of low serum calcium for at least 6 months prior to enrollment
2. Post-surgery (thyroid, parathyroid, neck) occurrence of hypoparathyroidism which is currently treated with calcium/calcitriol supplements to maintain a low/normal calcium (if the absence of PTH level) for at least 6 months prior to enrollment.
3. Post-surgery (thyroid, parathyroid, neck), both serum PTH and calcium low for at least 6 months post-surgery and continue to enrollment.
4. Non-surgical hypoparathyroidism requiring calcium/calcitriol supplements to maintain a low/normal calcium (if no PTH level available) for at least 6 months prior to enrollment
Signed informed consent and medical records released by the patient or a legally acceptable representative